Manu & Madre de Dios
Madre de Dios has Andean highlands, cloud forests and Amazonian jungle. It borders both Bolivia and Brazil. It is best known as a place to see wildlife (like the jaguar above I saw in Manu) and learn about the Indigenous Peoples who have inhabited the region for about 3,000 years. You can learn about them in Cusco and support Indigenous communities through buying their art at Xapiri Ground.
Madre de Dios is almost 7% of the territory of Peru but has only 0.4% of the population. The majority of the region is taken up by the Manu National Reserve, and the Bahuaja-Sonene National Park, which includes the Tambopata Reserve.